Figure 14.

The Wnt pathway leading to nuclear translocation of β-catenin is complex, but this greatly simplified figure shows that nuclear β-catenin is normally able to bind to Lef-1 and allow gene transcription (A), but cannot perform this function when Lef-1 is mutated (B). The dual mutations (E45K and S61P) in the N-terminal β-catenin interaction domain of Lef-1 demonstrated in a subset of sebaceous adenomas and sebaceomas blocks the interaction between these proteins and thus downstream gene transcription (C).