TABLE 2.
Differences in interleukin-6 (IL-6) and serum amyloid P (SAP) among participants in the Cardiovascular Health Study (CHS) according to usual alcohol intake, relative to long-term abstainers1
| Alcohol consumption category2 |
|||||||
|---|---|---|---|---|---|---|---|
| None (n = 704) | Former (n = 127) | <1 (<12) (n = 336) | 1-6 (12-72) (n = 290) | 7-13 (84-156) (n = 103) | ≥14 (≥168) (n = 133) | P for trend | |
| IL-6 (% difference) | |||||||
| All participants | Ref | 2 ± 93 | 3 ± 5 | -3 ± 5 | -3 ± 9 | 7 ± 8 | 0.37 |
| Apo E4 negative (n = 1143) | Ref | 3 ± 12 | 4 ± 6 | -7 ± 5 | -6 ± 11 | -3 ± 7 | 0.51 |
| Apo E4 positive (n = 365) | Ref | 13 ± 16 | 5 ± 9 | 13 ± 10 | 6 ± 16 | 48 ± 23 | 0.02 |
| IL-6C negative (n = 675) | Ref | 18 ± 18 | 1 ± 6 | -1 ± 7 | 6 ± 22 | 27 ± 14 | 0.02 |
| IL-6C positive (n = 850) | Ref | -2 ± 10 | 4 ± 7 | 1 ± 7 | -6 ± 10 | -3 ± 9 | 0.65 |
| SAP (mg/L difference) | |||||||
| All participants | Ref | -0.1 ± 1.4 | 0.2 ± 0.9 | -0.1 ± 0.8 | 0.5 ± 1.3 | 1 ± 1.2 | 0.48 |
Apo E4, apolipoprotein E4. Differences were derived from linear regression models adjusted for age, sex, race, current smoking, former smoking, marital status, education, income, leisure-time physical activity, BMI (linear and squared), depressive symptoms, arthritis, and diabetes and use of hormone replacement, aspirin, and statins, with weighting to reflect the probability of sampling from the full CHS population. Apo E4 positive indicates an apo E genotype of E2/E4, E3/E4, or E4/E4. IL-6C positive indicates a genotype of CC or GC. P values were derived from linear trend tests, excluding former drinkers. P values for interaction between alcohol use and genotype for IL-6 concentrations were 0.006 for apo E4 and 0.06 for IL-6C.
Drinks/wk; g ethanol in parentheses.
x̄ ± SE (all such values).