Table III. Comparisons of the PSC complex proteome with other cilia datasets.
NR, non-reciprocal; SAGE, serial analysis of gene expression.
| Study | Description | Proteins/genes reporteda |
Proteins/genes comparedb |
Shared with PSC complexc |
|---|---|---|---|---|
| Meta-analyses | ||||
| CiliaProteome V2 (16) | Non-redundant proteins in 10 previous studies | 1226 human (NRe−10) | 1224 mouse (NRe−10) | 344 (28%) |
| Ciliome (17) | Proteins found in ≥3 out of 9 cilia datasets | 196 (48 novel) | 164 (48 novel) | 78 (48%) (17 novel) |
| Proteomics | ||||
| Andersen et al. (37) | Human lymphoblast centrosomes | 112 | 112 | 61 (54%) |
| Broadhead et al. (12) | Trypanosome flagella | 331 | 166 | 42 (25%) |
| Keller et al. (13) | Chlamydomonas centrioles | 129 | 76 | 40 (53%) |
| Ostrowski et al. (9) | Human respiratory epithelial axonemes | 214 | 86 | 57 (66%) |
| Pazour et al. (10) | Chlamydomonas flagella | 652 | 333 | 137 (41%) |
| Smith et al. (11) | Tetrahymena cilia | 223 | 56 | 14 (25%) |
| Schmitt and Wolfrum (94) | Photoreceptor proteins (immunoscreen) | 24 | 24 | 21 (87.5%) |
| Bioinformatics | ||||
| Avidor-Reiss et al. (14) | Genomes of ciliated vs. non-ciliated organisms | 187 | 184 | 47 (26%) |
| Efimenko et al. (95) | Xbx genes C. elegans | 758 | 366 | 99 (27%) |
| Li et al. (15) | Genomes of ciliated vs. non-ciliated organisms | 688 | 427 | 88 (21%) |
| Gene expression | ||||
| Blacque et al. (96) | Xbx genes and SAGE analyses C. elegans cilia | 411 | 339 | 93 (27%) |
| Stolc et al. (97) | Gene expression Chlamydomonas flagella | 220 | 137 | 51 (37%) |
a
Number of genes/proteins reported is the number of published identifications.
b
Number of genes/proteins compared is the number of non-redundant proteins or genes for which human or mouse orthologs were identified.
c
Percentages are of the number of genes/proteins compared.