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LD50 determination for intranasnal LVS inoculation
| LVS inoculum (CFU)a | No. of surviving mice/total | Mean time to death ± SD (days) | Median survival (days) |
|---|---|---|---|
| 3.6×102 | 10/10 | Undefinedb | Undefined |
| 1.0×103 | 10/10 | Undefined | Undefiend |
| 3.2×104 | 8/10 | Undefined | Undefiend |
| 1.0×104 | 1/10 | 9.2 ± 4.3 | 9 |
| 2.9×104 | 0/10 | 10.3 ± 1.3 | 10 |
| 8.7×104 | 0/10 | 8.5 ± 1.4 | 8 |
| 2.6×105 | 0/10 | 7.9 ± 0.7 | 8 |
Mice were inoculated i.n. with the indicated number of LVS CFU
Survival exceeds 50% at the longest time point
