Table 2.

Maximal response (Emax) to Ach in experimental groups (CRC; concentration-response curves; NG; Normal Glucose, HG; High Glucose

(A) Males
	1st CRC in	2nd CRC in	3rd CRC in
Group n= 8	NG 77.8 ± 3.4	NG 76.9 ± 3.4	NG 73 ± 3.5
Group n = 8	NG 75.7 ± 5.6	NG 77.4 ± 5.2	HG 67.5 ± 5.6
Group n = 5	NG 72.2 ± 8.7	NG 75.4 ± 6.7	PMA 64.3 ± 8.8
(B) Females
Group n = 9	NG 84.5 ± 4.4	NG 86.9 ± 3.6	NG 83.4 ± 8.4
Group n = 9	NG 79.0 ± 4.0	NG 77.8 ± 4.6	HG 56.2 ± 4.3*
Group n = 5	NG 81.9 ± 4.0	LY379196 + NG 80.9 ± 4.2	LY379196 + HG 78.3 ± 5.4
Group n = 5	NG 80.7 ± 4.9	Fasudil + NG 81.0 ± 3.4	Fasudil + HG 57.5 ± 6.1*
Group n = 5	NG 96 ± 2.0	Ro-32-0432+ NG 93.3 ± 2.1	Ro-32-0432 + HG 73.4 ± 10.3*
Group n = 5	NG 93.7 ± 2.2	Rottlerin + NG 90.1 ± 3.5	Rottlerin+ HG 67.2 ± 3.9*
Group n = 5	NG 90.1 ± 3.4	LY341684 + NG 87.6 ± 5.7	LY341684 + HG 88.9 ± 5.9
Group n = 5	NG 88 ± 3.2	MnTMPyP + NG 87 ± 3.2	MnTMPyP+ HG 76 ± 0.6*
Group n = 5	NG 79.1 ± 3.1	NG 82.4 ± 2.8	PMA 62 ± 3.5*
Group n = 5	NG 81.9 ± 4.0	LY379196 + NG 80.9 ± 4.2	LY379196 + PMA 78.3 ± 5.4
Group n = 5	NG 78.0 ± 6.2	Fasudil + NG 79.8 ± 5.9	Fasudil + PMA 57.9 ± 5.8*
Group n = 5	NG 98.3 ± 2.1	Ro-32-0432 + NG 93.2 ± 4.1	Ro-32-0432 + PMA 73.0 ± 6.5*
Group n = 5	NG 96.3 ± 2.0	Rottlerin + NG 93.3 ± 4.0	Rottlerin + PMA 73.5 ± 6.5*
Group n = 5	NG 88.0 ± 5.2	LY341684 + NG 87.5 ± 4.2	LY341684 +PMA 88.6 ± 4.9
Group n = 5	NG 89.5 ± 3.1	MnTMPyP + NG 90.4 ± 4.6	MnTMPyP+ PMA 79.6 ± 2.9*

Data are expressed as Mean ± SEM (*P < 0.05 vs 2^nd CRC, paired t-test).