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. Author manuscript; available in PMC: 2008 Nov 1.
Published in final edited form as: Exp Neurol. 2007 Aug 22;208(1):110–119. doi: 10.1016/j.expneurol.2007.07.021

Figure 3.

Figure 3

Time course of the effects of systemic administration of levodopa (filled squares, 6 mg/kg, 1 injection per day, n=6) and levodopa+WIN (triangles, 1 mg/kg, i.p.) to rats with unilateral 6-OHDA lesions (n=6) on AIMs (as described in figure 2) measured at 100 min after levodopa injection (115 min after WIN injection). The CB1 antagonist AM251 (inverted triangle, 1 mg/kg., i.p. 15 min before WIN) was administered on day 12 of levodopa treatment. *p<0.05, **p<0.01 compared to rats treated with levodopa+vehicle; #p<0.05 compared to rats treated with levodopa+WIN (Kruskal-Wallis followed by Dunn's multiple comparison test. AM251 effect was analyzed by use of Friedman test followed by Dunn's multiple comparison test. Values represent median score. The interquartile ranges have been omitted for clarity).