Table 2.
Effect of p53 functional status on age at diagnosis in confirmed carriers considering only the first tumor
| p53 functional status
|
|||||
|---|---|---|---|---|---|
| PD | SD | O-SD | PDa* | SDa* | |
| No. | |||||
| Individuals | 80 | 151 | 104 | 40 | 191 |
| Families | 48 | 106 | 57 | 30 | 124 |
| Mean | |||||
| All individuals | 29.8 | 19.0 | 23.1 | 30.2 | 21.2 |
| Adjusted for family† | 26.9 | 18.2 | 21.8 | 26.1 | 19.7 |
| 95% confidence limits† | 21.6–32.3 | 15.6–20.9 | 18.3–25.4 | 18.0–34.1 | 17.2–22.1 |
| Median | |||||
| All individuals | 31 | 15 | 25 | 31.5 | 22 |
| Adjusted for family† | 29 | 14 | 24 | 27 | 17 |
| 95% confidence limits† | 21.5–36.4 | 9.9–18.1 | 15.3–32.7 | 13.0–41.0 | 11.8–22.2 |
| P values† (above diagonal for comparison of means and below for comparison of medians) | |||||
| PD | — | 0.004 | 0.12 | — | — |
| SD | 0.0007 | — | 0.11 | 0.07 | — |
| O-SD | 0.36 | 0.07 | — | 0.34 | 0.33 |
| PDa | — | 0.10 | 0.81 | — | 0.14 |
| SDa | — | — | 0.18 | 0.19 | — |
NOTE: Age at diagnosis was available for only a subset of individuals in the IARC database and the missing data could bias these comparisons.
*
For apoptotic REs.
†
Calculated using the within-cluster resampling method (24).