Table 3.

EGFR genotypes of cases and controls, and their association with the risk of lung cancer

Genotypes	Cases (n = 582), no.		Controls(n = 582), no.		P ‡	Crude OR (95% CI)	Adjusted OR¶ (95% CI)
	M/F†	Overall(%)	M/F†	Overall(%)
127378C>T
CC	194/59	253 (43.5)	196/61	257 (44.2)	0.61	1.00	1.00
CT	208/45	253 (43.5)	216/44	260 (44.7)		0.99(0.77–1.26)	1.00(0.78–1.28)
TT	65/11	76 (13.1)	55/10	65 (11.2)		1.19(0.82–1.73)	1.22(0.83–1.78)
T allele		0.348		0.335	0.51
142285G>A
GG	166/40	206 (35.4)	161/54	215 (36.9)	0.80	1.00	1.00
GA	218/61	279 (47.9)	224/44	268 (46.1)		1.09(0.84–1.40)	1.11(0.86–1.44)
AA	83/14	97 (16.7)	82/17	99 (17.0)		1.02(0.73–1.44)	1.05(0.74–1.48)
A allele		0.406		0.400	0.77
162093G>A
GG	337/89	426 (73.2)	343/86	429 (73.7)	0.54	1.00	1.00
GA	117/26	143 (24.6)	117/28	145 (24.9)		0.99(0.76–1.30)	0.96(0.73–1.26)
AA	13/0	13 (2.2)	7/1	8 (1.4)		1.64(0.67–3.99)	1.60(0.65–3.97)
A allele		0.145		0.138	0.63
181946C>T
CC	195/47	242 (41.6)	181/33	214 (36.8)	0.04	1.00	1.00
CT	221/47	268 (46.1)	212/55	267 (45.9)		0.89(0.69–1.14)	0.89(0.69–1.15)
TT	51/21	72 (12.4)	74/27	101 (17.4)		0.63(0.44–0.90)*	0.59(0.41–0.85)**
CC+CT	416/94	510 (87.6)	393/88	481 (82.6)	0.02	1.00	1.00
TT	51/21	72 (12.4)	74/27	101 (17.4)		0.67(0.49–0.93)*	0.63(0.45–0.88)***,****
T allele		0.354		0.403	0.01
187114T>C
TT	162/42	204 (35.1)	163/42	205 (35.2)	0.78	1.00	1.00
TC	215/54	269 (46.2)	219/58	277 (47.6)		0.98(0.76–1.26)	1.01(0.78–1.31)
CC	90/19	109 (18.7)	90/15	100 (17.2)		1.10(0.79–1.53)	1.16(0.83–1.63)
C allele		0.418		0.410	0.71

^† Male/Female.

^‡ Two-sided χ² test for either genotype distributions or allele frequencies between the cases and controls.

^¶ ORs (95% CIs) were calculated by conditional logistic analysis, adjusted for pack-years of smoking.

* P = 0.01.

** P = 0.005.

*** P = 0.007.

**** P = 0.32 for the interaction term between genotype and smoking status in the multivariate analysis.