Table 4.
Stratification analysis of the EGFR 181946C>T genotype frequencies in cases and controls
| Variable | Genotype, no (%) | ||||||
| Cases | Controls | Adjusted OR (95% CI) | |||||
| CC + CT | TT | CC+TT | TT | CC+TT | TT | P | |
| Smoking status | |||||||
| Never | 91 (82.7) | 19 (17.2) | 114 (82.6) | 24 (17.4) | 1.0 | 0.89 (0.45–1.75)† | 0.73 |
| Ever‡ | 419 (88.8) | 53 (11.2) | 367 (82.7) | 77 (17.3) | 1.0 | 0.59 (0.41–0.86)†, * | 0.007 |
| ≤ 38 pys | 168 (88.4) | 22 (11.6) | 226 (84.0) | 43 (16.0) | 1.0 | 0.64 (0.37–1.12)† | 0.12 |
| > 38 pys | 251 (89.0) | 31 (11.0) | 141 (80.6) | 34 (19.4) | 1.0 | 0.52 (0.30–0.88)† | 0.01 |
| Histologic types§ | |||||||
| Squamous cell ca. | 238 (88.1) | 32 (11.9) | 481 (82.6) | 101 (17.4) | 1.0 | 0.65 (0.41–1.01)¶ | |
| Adenoca. | 173 (84.4) | 32 (15.6) | 481 (82.6) | 101 (17.4) | 1.0 | 0.82 (0.52–1.28)¶ | |
| Small cell ca. | 90 (92.8) | 7 (7.2) | 481 (82.6) | 101 (17.4) | 1.0 | 0.32 (0.14–0.73)¶ | |
† Adjusted for age and pack-years of smoking.
‡ Current and former smoker.
§ Ten large cell carcinoma cases were excluded from this analysis.
¶ Adjusted for gender and pack-years of smoking.
* P = 0.08, test for homogeneity test between genotype-related ORs of never- and ever-smokers.