Table 5.
EGFR haplotype frequencies in the cases and controls, and their association with lung cancer risk
| Haplotype† | Controls (n = 1164) | Cases (n = 1164) | ||
| no. (%) | no. (%) | Adjusted§ OR (95% CI) | P | |
| CGGCT | 91 (7.8) | 118 (10.1) | 1.50 (1.09–2.07) | 0.012* |
| CGGCC | 124 (10.7) | 110 (9.5) | 1.08 (0.80–1.47) | 0.60 |
| CGGTT | 350 (30.1) | 305 (26.2) | 1.00 | |
| TAGCC | 227 (19.5) | 234 (20.1) | 1.24 (0.97–1.58) | 0.09 |
| Others‡ | 372 (32.0) | 397 (34.1) | 1.24 (0.98–1.54) | 0.07 |
| Global P | 0.08 | |||
† The order of polymorphisms is as follows: 117378C>T, 142285G>A, 162093G>A, 181946C>T and 187114T>C.
‡ Twenty-five haplotypes that had a frequency of less than 5%.
§ Adjusted for age, gender and pack-years of smoking.
* Bonferroni corrected P-value = 0.048.