Table 4.
Muscle size, strength, physical performance, physical activity, and self-reported physical functioning scores for patients receiving treatment with either 1,25 (OH)2D (calcitriol) or the analog paricalcitol
| Measure | Receiving calcitriol (n = 26) | Receiving paricalcitol (n = 23) | P value | ||
|---|---|---|---|---|---|
| Muscle Size | |||||
| Thigh Muscle CSA cm2 | 21 | 92.2 ± 5.7 | 16 | 119.3 ± 4 | 0.69 |
| Tibialis Anterior Muscle CSA cm2 | 25 | 9.7 ± 0.5 | 16 | 10.7 ± 0.6 | 0.88 |
| Isotonic Strength | |||||
| 3RM Knee Extension lbs | 17 | 18 ± 2 | 21 | 19 ± 2 | 0.49 |
| Isokinetic Strength | |||||
| Knee Extension Peak Torque at 90°/sec N·m | 22 | 40.09 ± 5.28 | 21 | 46.57 ± 5.78 | 0.27 |
| Knee Extension Peak Torque at 120°/sec N·m | 22 | 36.86 ± 5.45 | 21 | 40.90 ± 5.32 | 0.11 |
| Knee Extension Peak Torque at 180°/sec N·m | 22 | 26.18 ± 3.99 | 21 | 28.81 ± 4.15 | 0.16 |
| Isometric Strength | |||||
| Ankle Dorsiflexor MVC N | 16 | 195 ± 16 | 14 | 208 ± 20 | 0.68 |
| Physical Performance | |||||
| Normal Gait Speed cm/sec | 25 | 94.1 ± 7.6 | 23 | 108.3 ± 6.1 | 0.73 |
| Fast Gait Speed cm/sec | 24 | 127.4 ± 9.8 | 22 | 147.6 ± 8.0 | 0.96 |
| Stair Climb sec | 25 | 12.9 ± 1.8 | 22 | 10.0 ± 1.3 | 0.74 |
| Fast Stair Climb sec | 21 | 7.8 ± 1.0 | 18 | 5.2 ± 0.4 | 0.15 |
| Sit-to-Stand 5 times sec | 25 | 19.5 ± 2.1 | 23 | 15.1 ± 1.7 | 0.82 |
| Get-up-and-Go sec | 25 | 14.7 ± 2.3 | 23 | 10.4 ± 1.0 | 0.97 |
| Physical Activity | |||||
| Daily Activity: Accelerometry, arb. units | 21 | 55,872 ± 10,311 | 17 | 66,597 ± 9,751 | 0.92 |
| Self-Reported Functioning | |||||
| SF-36 PF Questionnaire | 22 | 45 ± 6 | 21 | 61 ± 6 | 0.16 |
| HAP Questionnaire | 24 | 56 ± 4 | 20 | 52 ± 5 | 0.70 |
Data are mean ± SEM. Abbreviations: CSA, cross-sectional Area; 3RM, three-repetition maximum; MVC, maximal voluntary contraction; N·m, Newton-meters; N, newtons; SF-36 PF; Medical Outcomes Study 36-Item Short Form health status questionnaire physical function score, HAP AAS; Human Activity Profile adjusted activity score