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Effect of chronic hypoxia of 9 to 24 hours on HIF1α hydroxylation. Model results show the amount of hydroxylated [HIF1α] per [PHD2] for four different ratios of PHD2 synthesis rate to HIF1α synthesis rate relative to the maximum [HIF1α]hydroxylated/[PHD2]. HIF1α synthesis is a function of [O2] and duration of hypoxia, whereas PHD2 synthesis is a function of [HIF1α] and duration of hypoxia. HIF1α accumulation begins at 4 hours, and measurable PHD2 synthesis follows at 8 hours.
