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. Author manuscript; available in PMC: 2008 Nov 9.
Published in final edited form as: J Mol Biol. 2007 Aug 23;373(5):1123–1140. doi: 10.1016/j.jmb.2007.07.079

Table 2.

Occupancy of Hydrogen Bonds Between Platinum Amine Hydrogens and Nearby Bases on the DNA

Pattern of H Bond Formation % Occupancy of H Bond
5' Side 3' Side
A: CP-DNA Adduct
Pt-amine-H • A5 Pt-amine-H • G7
+ − 40.2%
+ + 34.0%
− + 13.3%
− − 12.5%
B: OX-DNA Adduct
Pt-amine-axial-H • A5 Pt-amine-equitorial-H • G7
+ − 7.7%
+ + 3.5%
Pt-amine-equitorial-H • A5 Pt-amine-equitorial-H • G7
+ − 6.0%
+ + 40.9%
No Pt-amine-H • A5 Pt-amine-equitorial-H • G7
− + 34.3%
− − 7.6%

The percentage occupancy of hydrogen bonds between Pt-amine hydrogens and near-by DNA bases (see Figure 5) was calculated as described in Methods.