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. 2007 Dec 13;118(1):124–132. doi: 10.1172/JCI33255

Figure 5. Decreased hypertrophic response of Mef2d mutant mice following β-adrenergic stimulation.

Figure 5

(A) WT and Mef2d mutant mice were chronically infused with either saline vehicle or ISO (8.8 mg/kg/day) for 7 days and sacrificed for assessment of cardiac remodeling. HW/TL ratios (±SEM) are shown as bar graphs (n = 7–9 per group). n.s., non-significant. (B) Whole hearts of WT and Mef2d mutant mice treated with either saline vehicle or ISO (8.8 mg/kg/day) are shown at the top. Hearts were sectioned and stained with H&E as seen on bottom. Scale bar: 1 mm. (C) Representative bar graphs indicating less LV dilation and a decrease in FS in Mef2d mutant mice compared with WT mice in response to ISO treatment.