Figure 5.
Sequence alignment of regions from various fibrinogen β, γ, and αE chains and the partial sequence of a lectin from the slug, Limax flavus. (26). FBEH, human β; FBER, rat β; FBEC, chicken β; FBEL, lamprey β; FGAH, human γ; FGAR, rat γ; FGAC, chicken γ; FGAL, lamprey γ; FAH2, human αE; FAR2, rat αE; FAC2, chicken αE; and FAL2, lamprey αE. Only the human sequences are numbered. Those residues in which all 12 nonslug sequences are identical are emboldened, as are two key residues (∗∗) from the binding pocket in which the slug lectin is the same as three of the αEC domains. The skein at αE809–818 in which the αEC differs significantly from β and γ chains is denoted by ∗∗∗∗∗∗∗∗∗∗. The sequence of the remainder of the slug lectin has not yet been reported.