Figure 1.

Human CAD cDNA. (A) Nucleotide sequences of human CAD cDNA and the CAD pseudogene. The nucleotide sequence of human CAD cDNA (upper line) is shown with that of the pseudogene (lower line). The dashed line indicates identity between the two sequences. The dots indicate positions where the corresponding nucleotides are deleted. The amino acid sequence of human CAD was deduced from the cDNA nucleotide sequence and is numbered starting from Met-1. (B) Alignment of the amino acid sequences of human CAD with mouse CAD. The identical amino acids are shown in bold. The conserved cysteine residues and the putative nuclear localization signal are indicated by double and single underlines, respectively. The amino acid sequence of murine CAD is from DNA Data Base in Japan/GenBank/European Molecular Biology Laboratory (accession no. AB009377).