Figure 6.

An N-terminal domain homologous between CAD and ICAD. The N-terminal amino acid sequences of human CAD (hCAD), mouse CAD (mCAD), human DFF-45/ICAD (hDFF-45), and mouse ICAD (mICAD) are aligned to give maximum homology by introducing several gaps (−). The residues identical in at least three of four members are shown in bold, and residues regarded as favored substitutions are underlined. Favored amino acid substitutions are defined as pairs of residues belonging to one of the following groups: S, T, P, A, and G; N, D, E, and Q; H, R, and K; M, I, L, and V; F, Y, and W.