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. 1975 Oct;75(2):315–332. doi: 10.1017/s0022172400047331

An investigation of the family background of acute Haemophilus infections of children.

D C Turk
PMCID: PMC2130303  PMID: 1080769

Abstract

Nose and throat swabs, for culture of Haemophilus influenza type b, and blood samples, for measurement of antibodies specific for that serotype, were collected from members of 28 families from which children had been admitted to hospital with acute H. influenzae type b infections (mainly meningitis or epiglottitis). The patients with meningitis were younger than those with epiglottitis and had more siblings, with a marked predominance of sisters. Investigations within a few days of admission of the affected children to hospital detected carriers of H. influenzae type b (19 altogether) in 13 of the 28 families, including 9 of the 13 families with 3 or more children. Members with raised antibody titres for H. influenzae type b (suggesting the presence of the organism for at least a few weeks) were found in 17 of the 25 families from which blood samples were obtained, including all 11 families with 3 or more children. Most of the patients probably acquired their infections from within their own families, and siblings under 11 years old were of predominant importance both as carriers and as potential sources of the patients' infections. Persistence of the organism within families for up to 6 months was demonstrated. Possible reasons for the difference in age-incidence between haemophilus meningitis and epiglottitis and for the occurrence of the former in babies with older sisters are suggested, and also a possible connection between the results of this survey and the likely value of immunization against H. influenzae type b.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERENBERG W., KEVY S. Acute epiglottitis in childhood; a serious emergency, readily recognized at the bedside. N Engl J Med. 1958 May 1;258(18):870–874. doi: 10.1056/NEJM195805012581802. [DOI] [PubMed] [Google Scholar]
  2. Barrett F. F., Taber L. H., Morris C. R., Stephenson W. B., Clark D. J., Yow M. D. A 12 year review of the antibiotic management of Hemophilus influenzae meningitis. Comparison of ampicillin and conventional therapy including chloramphenicol. J Pediatr. 1972 Aug;81(2):370–377. doi: 10.1016/s0022-3476(72)80316-0. [DOI] [PubMed] [Google Scholar]
  3. Bass J. W., Steele R. W., Wiebe R. A. Acute epiglottitis. A surgical emergency. JAMA. 1974 Aug 5;229(6):671–675. [PubMed] [Google Scholar]
  4. Baxter J. D. Acute epiglottitis in children. Laryngoscope. 1967 Aug;77(8):1358–1367. doi: 10.1288/00005537-196708000-00011. [DOI] [PubMed] [Google Scholar]
  5. Bennett J. V., McCormick J. B., Feldman R. A. Letter: Hemophilus influenzae meningitis. Pediatrics. 1974 Jun;53(6):951–952. [PubMed] [Google Scholar]
  6. Bevan-Jones H., Miller D. L. Bacterial meningitis, 1962-63. Mon Bull Minist Health Public Health Lab Serv. 1967 Feb;26:22–30. [PubMed] [Google Scholar]
  7. CAMPS F. E., JONES H. M. Acute epiglottitis: supraglottitis. Practitioner. 1957 Feb;178(1064):223–229. [PubMed] [Google Scholar]
  8. Cartwright K., Turk D. C. Letter: Haemophilus influenzae. Br Med J. 1974 Apr 27;2(5912):225–225. doi: 10.1136/bmj.2.5912.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DAWSON B., ZINNEMANN K. Incidence and type distribution of capsulated H. influenzae strains. Br Med J. 1952 Apr 5;1(4761):740–742. doi: 10.1136/bmj.1.4761.740. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Johnston R. B., Jr, Anderson P., Rosen F. S., Smith D. H. Characterization of human antibody to polyribophosphate, the capsular antigen of Hemophilus influenzae, type B. Clin Immunol Immunopathol. 1973 Jan;1(2):234–240. doi: 10.1016/0090-1229(73)90024-x. [DOI] [PubMed] [Google Scholar]
  11. Johnstone J. M., Lawy H. S. Acute epiglottitis in adults due to infection with Haemophilus influenzae type b. Lancet. 1967 Jul 15;2(7507):134–136. doi: 10.1016/s0140-6736(67)92968-6. [DOI] [PubMed] [Google Scholar]
  12. Jones H. M. Acute epiglottitis: a personal study over twenty years. Proc R Soc Med. 1970 Jul;63(7):706–712. [PMC free article] [PubMed] [Google Scholar]
  13. KOCH R., CARSON M. J. Management of Hemophilus influenzae, type B, meningitis; analysis of 128 cases. J Pediatr. 1955 Jan;46(1):18–29. doi: 10.1016/s0022-3476(55)80234-x. [DOI] [PubMed] [Google Scholar]
  14. MASTERS P. L., BRUMFITT W., MENDEZ R. L., LIKAR M. Bacterial flora of the upper respiratory tract in Paddington families. 1952-4. Br Med J. 1958 May 24;1(5081):1200–1205. doi: 10.1136/bmj.1.5081.1200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. MILLER I. A., TURK D. C. HAEMOPHILUS INFLUENZAE INFECTION OF A FINGER. Br Med J. 1965 Apr 17;1(5441):1042–1042. doi: 10.1136/bmj.1.5441.1042. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. McGowan J. E., Jr, Klein J. O., Bratton L., Barnes M. W., Finland M. Meningitis and bacteremia due to Haemophilus influenzae: occurrence and mortality at Boston City Hospital in 12 selected years, 1935-1972. J Infect Dis. 1974 Aug;130(2):119–124. doi: 10.1093/infdis/130.2.119. [DOI] [PubMed] [Google Scholar]
  17. Milko D. A., Marshak G., Striker T. W. Nasotracheal intubation in the treatment of acute epiglottitis. Pediatrics. 1974 May;53(5):674–677. [PubMed] [Google Scholar]
  18. Mpairwe Y. Observations on the nasopharyngeal carriage of Haemophilus influenzae type b in children in Kampala, Uganda. J Hyg (Lond) 1970 Jun;68(2):337–341. doi: 10.1017/s0022172400028783. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Myerowitz R. L., Gordon R. E., Robbins J. B. Polysaccharides of the genus Bacillus cross-reactive with the capsular polysaccharides of Diplococcus pneumoniae type 3, Haemophilus influenzae type b, and Neisseria meningitidis group A. Infect Immun. 1973 Dec;8(6):896–900. doi: 10.1128/iai.8.6.896-900.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Norden C. W., Melish M., Overall J. C., Jr, Baum J. Immunologic responses to Hemophilus influenzae meningitis. J Pediatr. 1972 Feb;80(2):209–214. doi: 10.1016/s0022-3476(72)80580-8. [DOI] [PubMed] [Google Scholar]
  21. Norden C. W., Michaels R. Immunologic response in patients with epiglottitis caused by Haemophilus influenzae type b. J Infect Dis. 1973 Dec;128(6):777–780. doi: 10.1093/infdis/128.6.777. [DOI] [PubMed] [Google Scholar]
  22. OUNSTED C. Haemophilus influenzae meningitis; a possible ecological factor. Lancet. 1950 Jan 28;1(6596):161–161. doi: 10.1016/s0140-6736(50)90262-5. [DOI] [PubMed] [Google Scholar]
  23. OUYANG H. M., TING T. T. Hemophilus influenzae meningitis; an analysis of 120 cases. Chin Med J. 1957 Nov;75(11):908–916. [PubMed] [Google Scholar]
  24. Parke J. C., Jr, Schneerson R., Robbins J. B. The attack rate, age incidence, racial distribution, and case fatality rate of Hemophilus influenzae type b meningitis in Mecklenbury County, North Carolina. J Pediatr. 1972 Oct;81(4):765–769. doi: 10.1016/s0022-3476(72)80099-4. [DOI] [PubMed] [Google Scholar]
  25. SHAW E. B., BRUYN H. B. Streptomycin in therapy of Hemophilius inflenzae meningitis. J Pediatr. 1960 Feb;56:253–258. doi: 10.1016/s0022-3476(60)80124-2. [DOI] [PubMed] [Google Scholar]
  26. Schneerson R., Bradshaw M., Whisnant J. K., Myerowitz R. L., Parke J. C., Jr, Robbins J. B. An Escherichia coli antigen cross-reactive with the capsular polysaccharide of Haemophilus influenzae type b: occurrence among known serotypes, and immunochemical and biologic properties of E. coli antisera toward H. influenzae type b. J Immunol. 1972 Jun;108(6):1551–1562. [PubMed] [Google Scholar]
  27. Sell S. H. The clinical importance of Hemophilus influenzae infections in children. Pediatr Clin North Am. 1970 May;17(2):415–426. doi: 10.1016/s0031-3955(16)32419-1. [DOI] [PubMed] [Google Scholar]
  28. Smith D. H., Ingram D. L., Smith A. L., Gilles F., Bresnan M. J. Bacterial meningitis. A symposium. Pediatrics. 1973 Oct;52(4):586–600. [PubMed] [Google Scholar]
  29. Smith D. H., Peter G., Ingram D. L., Harding A. L., Anderson P. Responses of children immunized with the capsular polysaccharide of Hemophilus influenzae, type b. Pediatrics. 1973 Nov;52(5):637–644. [PubMed] [Google Scholar]
  30. South M. A. Lack of immune response to Hemophilus influenzae: immune paralysis or immaturity? J Pediatr. 1972 Feb;80(2):348–350. doi: 10.1016/s0022-3476(72)80622-x. [DOI] [PubMed] [Google Scholar]
  31. THRUPP L. D., LEEDOM J. M., IVLER D., WEHRLE P. F., BROWN J. F., MATHIES A. W., PORTNOY B. H. INFLUENZAE MENINGITIS: A CONTROLLED STUDY OF TREATMENT WITH AMPICILLIN. Postgrad Med J. 1964 Dec;40:SUPPL–SUPPL:126. doi: 10.1136/pgmj.40.suppl.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. TURK D. C., GREEN C. A. MEASUREMENT OF ANTIBODIES REACTING WITH CAPSULAR ANTIGENS OF HAEMOPHILUS INFLUENZAE. J Clin Pathol. 1964 May;17:294–296. doi: 10.1136/jcp.17.3.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. TURK D. C. Naso-pharyngeal carriage of Haemophilus influenza type B. J Hyg (Lond) 1963 Jun;61:247–256. doi: 10.1017/s0022172400020957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. TURK D. C., WYNTER H. H. Meningitis in Jamaica, 1958-1960. West Indian Med J. 1961 Jun;10:118–131. [PubMed] [Google Scholar]
  35. Turk D. C., Holdaway M. D. Capsulated Haemophilus influenzae and bronchiectasis. J Med Microbiol. 1968 Aug;1(1):79–88. doi: 10.1099/00222615-1-1-79. [DOI] [PubMed] [Google Scholar]

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