Table 2.

Alignment of the four domains conserved in all CMP–Neu5Ac synthetases

Species	aa	motif I	aa	motif II	aa	motif III	aa	motif IV	Acc. no.
mouse	45	ALVLARGGSKGIPLKN	83	FQSVWVSTD	140	IQATSPCL	209	LYENGSFYF	AJ006215†
Haemophilus influenzae	9	AIIPARAGSKGIKDKN	47	FDQIVVTSD	105	LQPTSPLR	173	YRANGAIYI	U32807‡
N. meningitidis	7	AVILARQNSKGLPLKN	45	FDRIIVSTD	103	LQPTSPLR	172	FRPNGAIYI	X78068†
E. coli	7	AIIPARSGSKGLRNKN	45	FEKVIVTTD	102	LQPTSPFR	170	YHPNGAIFI	P13266*
Streptococcus agalactiae	5	CIIPARSGSKGLPDKN	45	KKDIFVSTD	102	LQVTSPLR	170	YYPNGAIFI	U19899†
Haemophilus ducreyi	5	AIIPARAGSKGIKDKN	43	FDHIIVSSD	100	IQPTSPLR	169	YRANGAIYI	U54496‡
Helicobacter pylori	5	AIVLARSSSKRIKNKN	43	FEKVFISSD			170	YHDAGLLYM	AE000550‡
Consensus sequence		AIIpAR-GSKGi--KN		F--i-VStD		LQPTSPLR		Y--NGAIYI

The table aligns the four amino acid stretches of high conservation contained in the murine and bacterial enzymes. Numbers indicate the amino acid residue, with which the motifs start. In the consensus sequence, amino acid residues identical in at least five of seven sequences are shown as capital letters; those conserved in at least four sequences are shown in small letters. Boxed residues are identical for all species. Abbreviations: aa, amino acids; acc. no., accession number. 

^*SwissProt database. 

^†European Molecular Biology Laboratory database. 

^‡GenBank database.