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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1925 Mar 31;41(4):487–502. doi: 10.1084/jem.41.4.487

STUDIES IN EXPERIMENTAL SYPHILIS

II. THE INFLUENCE OF A NON-SPECIFIC INFLAMMATORY REACTION UPON THE DEVELOPMENT OF THE CHANCRE.

Alan M Chesney 1, Jarold E Kemp 1
PMCID: PMC2130955  PMID: 19869004

Abstract

Rabbits can be successfully infected with syphilis by the inoculation of surface wounds with virulent strains of Treponema pallidum. Old granulating wounds in these animals constitute a particularly favorable terrain for syphilis inoculation, the chancre developing relatively soon and attaining a greater size than the lesion occurring on the basis of a fresh wound. Coal tar dermatitis renders the skin susceptible to infection with Treponema pallidum. The possible reasons for these phenomena are discussed and an hypothesis to account for them is advanced.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown W. H., Pearce L. PENETRATION OF NORMAL MUCOUS MEMBRANES OF THE RABBIT BY TREPONEMA PALLIDUM AND THE INFLUENCE OF THIS MODE OF INFECTION UPON THE COURSE OF THE DISEASE. J Exp Med. 1924 Apr 30;39(5):645–658. doi: 10.1084/jem.39.5.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
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