Human E2F-6 sequence. (A) Nucleotide sequence of a cDNA encoding human E2F-6 and the predicted amino acid sequence. The E2F-6 sequence has been submitted to the EMBL/GeneBank database (accession no. AF059292). (B) (Upper) Schematic comparison of E2F-6 with E2F-1, -2, and -3 and E2F-4 and -5. Shaded boxes indicate homologous regions. cA, cyclin A binding site; DB, DNA-binding domain; DIM, dimerization domain; MB, marked box; PB,TA, pocket protein and transactivation domain. (Lower) Homology (as expressed in percent identity in the indicated domains) between E2F-6 and E2F-1 and -4.