Skip to main content
. Author manuscript; available in PMC: 2008 Nov 1.
Published in final edited form as: Am J Obstet Gynecol. 2007 Nov;197(5):486.e1–486.10. doi: 10.1016/j.ajog.2007.04.019

Table IV.

Meta-analysis of observational studies with recent exposure to antenatal indomethacin (AI)

Neonatal Outcome Reference # Infants exposed to AI # Infants unexposed to AI Random-effects Odds ratio (95% C.I) Heterogeneity Test p-value
IVH 23,31,32, 35,37,41 337 424 1.18 (0.57 – 2.4) 0.003
Grade III–IV IVH 23,31,32, 35,37 299 396 1.3 ( 0.5 – 3.2) 0.04
PVL 35,37 144 151 N/A N/A
NEC 23,27,31, 32,35 268 1016 2.23 (1.16 – 4.25) 0.23
BPD 23,41 86 89 N/A N/A
PDA 23,31,32, 35,37,41 337 434 1.05 (0.61 – 1.8) 0.01
RDS 23,35,37,41 239 246 2.2 (0.94 – 5.12) 0.02
Mortality 23,31,32, 35,37,41 339 436 1.15 (0.7 – 1.88) 0.2

N/A denotes not applicable