Table 2.
Cox Proportional Hazards Regression Analysis of SNPs in SORL11
| SORL1 SNPs | Physical map location (bp) | Total2 | Multivariable Analysis3 | ||
|---|---|---|---|---|---|
| Affected2 | HR | 95% C.I. | |||
| rs4935774 | 120826964 | ||||
| GG | 15 | 6 | 1.15 | 0.48 – 2.8 | |
| At least one A | 188 | 48 | 1.0 | Reference | |
| rs578506 | 120828687 | ||||
| CC | 49 | 14 | 0.96 | 0.53 – 1.7 | |
| At least one G | 154 | 40 | 1.0 | Reference | |
| rs536360 | 120833247 | ||||
| CC | 35 | 6 | 0.40 | 0.16 – 0.98 | |
| At least one A | 168 | 47 | 1.0 | Reference | |
| rs668387 | 120873131 | ||||
| TT | 32 | 8 | 1.05 | 0.4 – 2.5 | |
| At least one C | 176 | 45 | 1.0 | Reference | |
| rs2298813 | 120898894 | ||||
| GA | 16 | 4 | 0.78 | 0.36 – 1.1 | |
| GG | 189 | 50 | 1.0 | Reference | |
| rs556349 | 120931417 | ||||
| TT | 24 | 3 | 0.26 | 0.08 – 0.86 | |
| At least one G | 184 | 50 | 1.0. | reference | |
| rs1699102 | 120962172 | ||||
| CC | 22 | 3 | 0.33 | 0.09 – 1.09 | |
| At least one T | 183 | 51 | 1.0 | reference | |
Cox Proportional Hazards Model
Only the genotyped individuals are included in the analyses.
Multivariable analysis includes sex, level of mental function and the presence of the APOE ε4 allele