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. Author manuscript; available in PMC: 2007 Dec 11.
Published in final edited form as: Hum Mol Genet. 2007 Aug 27;16(22):2729–2739. doi: 10.1093/hmg/ddm227

Figure 3.

Figure 3

Modeled structure of the wild type, Y955C pol γ or the T7 DNA pol structure with 8-oxo-dG in the template. (A) T7 DNA pol with incoming dCTP. (B) T7 DNA pol with incoming dATP. (C) Wild-type pol γ with incoming dCTP. (D) Wild-type pol γ with incoming dATP. (E) Y955C mutant pol γ with incoming dCTP. (F) Y955C mutant pol γ with incoming dATP. The 8-oxo-dG is labeled in each panel and is shown in the anti-conformation in A, C and E, and shown in the syn-conformation in B, D, and F. The structure of the wild-type T7 pol with 8-oxo-dG in panel A was derived from PDB: 1TKO (20) with Lys536 and Tyr530 labeled. The structure of the K536A derivative of T7 pol in B was derived from PDB: 1ZYQ (23) with Ala536 labeled.