. Author manuscript; available in PMC: 2007 Dec 11.

Published in final edited form as: Mamm Genome. 2007 Nov 16;18(12):839–851. doi: 10.1007/s00335-007-9069-6

Table 4.

Summary of genome scan results and comparison with other QTLs

Chr	Phenotype	Marker^a	Peak (CI) (cM)	LOD score^b	Mode^c	Plus allele	ΔLOD^d	Sex effect^e	QTL symbol and previous references^f
1	Percent fat	D1MIT440.1	54 (43–66)	2.3^*	recessive	B6	0.03		Fatq1 (Moody et al. 1999)
2	Body weight	D2MIT285.1	86 (78–92)	6.5^***	free	B6	1.91	M	Pbwg11 (Ishikawa et al. 2005); D2Mit22 (Cheverud et al. 1996); Bw20 (Vitarius et al. 2006)
2	Fat weight	D2MIT293.1	11 (0–15)	2.8^*	dominant^#	B6	0.12		Adip10 (Stylianou et al. 2006)
2	Percent fat	D2MIT285.1	86 (72–98)	3.8^**	dominant	B6	0.39		Gnf3 (Jerez-Timaure et al. 2005)
3	Body weight	D3MIT57.1	55 (45–67)	5.8^***	free	B6	1.52	M	Wt10Q2 (Moody et al. 1999)
3	Lean weight	D3MIT5	25 (17–36)	3.6^**	dominant	B6	0.36		Bwtq13 this report
3	Fat weight	D3MIT5	25 (14–32)	4.6^***	dominant	B6	0.48		Afw1 (Brockmann et al. 2000)
3	Percent fat	D3MIT256.1	66 (57–72)	3.0^*	dominant	B6	2.62	M	Afp(1) (Brockmann et al. 1998)
4	Body weight	D4MIT17.1	32 (26–43)	5.6^***	free	B6	1.65	M	Bw6b (Keightley et al. 1996)
4	Lean weight	D4MIT17.1	32 (13–39)	4.1^***	additive	B6	0.79		Epb4.1 (Moody et al. 1999) (body weight)
4	Fat weight	D4MIT17.1	32 (17–46)	3.5^**	dominant	B6	0.31		Adip11 (Stylianou et al. 2006)
5	Body weight	D5MIT123.1	3 (0–10)	4.7^***	free	B6	0.70		Bwq8 this report^#
5	Lean weight	rs3719351	49 (43–55)	4.7^***	free	B6	0.14		Bw6d (Keightley et al. 1996); Bwob (Ewart-Toland et al. 1999) (body weight)
5	Fat weight	D5MIT314.1	59 (42–71)	2.0^*	additive	B6	0.77		Afw(3) (Brockmann et al. 1998)
6	Body weight	D6MIT198.1	67 (52–79)	2.2^*	dominant	PWK	0.41		Body weight QTL 3 (Anunciado et al. 2001); Bwtq10 (Stylianou et al. 2006)
6	Percent fat	D6MIT284.1	38 (26–47)	2.8^*	additive	PWK	0.32		Pfat2 (Keightley et al. 1998)
7	Body weight	D7MIT223.1	72 (58–79)	2.8^*	dominant	B6	1.46	M	Pbwg3 (Ishikawa et al. 2005)
9	Body weight	D9MIT129.1	26 (15–41)	2.1^*	free	PWK	0.96		Bodw4 (Carlborg et al. 2005); Bwnd4wk5 (Brockmann et al. 2004)
9	Lean weight	D9MIT123.1	42 (26–55)	2.5^*	dominant	B6	1.24	F	D9Mit164 (Brockmann et al. 2000) (body weight)
9	Percent fat	D9MIT123.1	42 (33–49)	2.8^*	free	PWK	0.43		Adip5 (McDaniel et al. 2006)
10	Body weight	D10MIT96.1	56 (32–65)	2.9^*	recessive	B6	0.92		D10Mit10 (Cheverud et al. 1996)
10	Percent fat	D10MIT96.1	56 (49–61)	2.3^*	recessive	B6	0.61		Adip15 (Stylianou et al. 2006)
11	Body weight	D11MIT285.1	52 (44–67)	4.8^***	free	PWK	2.35	M	Bw4 (Brockmann et al. 2004)
11	Percent fat	D11MIT285.1	52 (47–57)	5.8^***	free	PWK	3.16	M	Adip19 this report^§
13	Fat weight	D13MIT144.1	48 (37–59)	4.0^**	dominant	B6	0.75		Fatpad3 (Yi et al. 2006)
13	Lean weight	D13MIT144.1	48 (39–56)	3.2^*	dominant	B6	0.58		Bw10 (Brockmann et al. 2000) (body weight)
16	Lean weight	D16MIT107.1	3 (0–16)	1.9^*	additive	PWK	0.28		Fatq1 (Moody et al. 1999)
16	Fat weight	D16MIT107.1	3 (0–11)	2.2^*	dominant^#	B6	0.18		Adip17 (Stylianou et al. 2006)

Chr = chromosome; CI = confidence interval

Marker positions in Mb were obtained using the University of California at San Diego Genome Bioinformatics browser (Kent et al. 2002) accessing Build 36 of the mouse genome, see Web References

LOD score for corresponding mode of inheritance. Genome-wide significance determined by permutation tests:

^***

p<0.01;

^**

p< 0.05;

p < 0.63

Mode = estimate by MAPMAKER/QTL for additive, dominant/recessive and unconstrained (free) models. # indicates that the dominant allele reduced the trait value

ΔLOD indicates the difference between a model with sex as additive or additive and interactive covariate

Sex effect indicates a QTL that is either sex-biased (ΔLOD>0.9) or sex-specific/sex antagonistic (ΔLOD>3.1); M = male-biased QTL, F = female-biased QTL

List of QTLs: When the previous QTL was for a slightly different trait, the original trait is given in parentheses, e.g., (body weight). The list of overlapping QTLs is representative and does not include every QTL known to map to the region.

After Bwq8 was assigned to this locus but before publication, an overlapping QTL (Bw21) was reported (Vitarius et al. 2006).

^§

An unnamed QTL for an adiposity index maps near here (Collin et al. 2005) but it has features that suggest it is not equivalent to Adip19