TABLE III.

RACE-SPECIFIC EFFECTS OF CLINICAL FACTORS ON MEAN PhIP-DNA ADDUCT LEVELS IN PROSTATE TUMOR AND NON-TUMOR CELLS¹

	Caucasians (n = 162)		African–Americans (n = 102)		AA race × risk factor interaction
	B ± SE	p value	β ± SE	p value	β ± SE	p value
Older Age at prostatectomy (≥60)
Tumor	−0.003 ± 0.004	0.43	0.009 ± 0.005	0.10	0.012 ± 0.007	0.08
Non-tumor	−0.002 ± 0.007	0.77	0.006 ± 0.009	0.52	0.013 ± 0.011	0.24
PSA at diagnosis Tumor
Tumor
Moderate (4–10 ng/mL)	−0.0006 ± 0.005	0.90	0.007 ± 0.009	0.42	0.006 ± 0.010	0.55
High (>10 ng/mL)	−0.005 ± 0.007	0.49	0.018 ± 0.012	0.11	0.019 ± 0.012	0.12
Non-tumor
Moderate (4–10 ng/mL)	0.010 ± 0.008	0.22	0.016 ± 0.015	0.29	0.010 ± 0.016	0.55
High (>10 ng/mL)	0.009 ± 0.011	0.40	0.019 ± 0.020	0.35	0.023 ± 0.021	0.26
High tumor volume (≥20%)
Tumor	−0.014 ± 0.004	0.002	−0.012 ± 0.005	0.03	0.004 ± 0.007	0.57
Non-tumor	−0.021 ± 0.007	0.003	−0.011 ± 0.009	0.24	0.014 ± 0.011	0.20
High Prostate Volume (≥65 cc)
Tumor	−0.005 ± 0.004	0.22	−0.018 ± 0.005	0.001	−0.008 ± 0.007	0.25
Non-tumor	−0.014 ± 0.007	0.04	−0.009 ± 0.009	0.33	0.007 ± 0.011	0.54
Advanced tumor stage (3 or 4)
Tumor	0.004 ± 0.005	0.51	−0.012 ± 0.007	0.11	−0.004 ± 0.008	0.61
Non-tumor	0.0008 ± 0.009	0.93	−0.001 ± 0.012	0.94	0.013 ± 0.013	0.30
Advanced Gleason Grade2
Tumor	0.003 ± 0.005	0.57	0.013 ± 0.007	0.06	0.010 ± 0.008	0.19
Non-tumor	0.003 ± 0.008	0.70	0.029 ± 0.012	0.02	0.029 ± 0.013	0.02

¹All beta estimates adjusted for the other five clinical factors.

²Gleason sum 8 or higher or Gleason sum 7 and primary Gleason grade 4 or higher.