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. 2007 Nov 13;3:145. doi: 10.1038/msb4100187

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Copyright © 2007, EMBO and Nature Publishing Group

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.

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Repression is effective at all three positions, following the trend core⩾proximal⩾distal. Measurements of repressed single-input promoters. Responses are colored according to the repressor: LacI (filled) or TetR (open). Each promoter contains a single operator located at distal (A), core (B), or proximal (C) positions. Single-input activities are plotted in the induced (unregulated) versus uninduced (repressed) states. In some promoters, operators do not effectively repress the promoter (points located near solid black line). Luciferase detection limits are shown with gray dashed lines.