Table I.

Sequence Comparison of ADF1 from Arabidopsis thaliana with Other Members of the ADF/Cofilin Family

Organism		Amino acid sequence
Yeast		MSRSGVAVADESLTAFNDLKLGK---------KYKFILFGLNDAKTEIVVK-----------ETSTDPSYDAFLEKLPENDCLYAIYDFEY
Dict. D.		SSGIALAPNCVSTFNDLKLGR---------KYGGIIYRISDDSKEIIVD----------STLPAGCSFDEFTKCLPENECRYVVLDYQY
Ac. Cast.		MSGIAVSDDCVQKFNELKLGHQH-------RYVTFKMNA--SNTEVVVEH--------VGG-PNAT-YEDFKSQLPERDCRYAIFDYEF
A.T.		MANAASGMAVHDDCKLRFLELKAKRTH-------RFIVYKIEE--KQKQVVVE--K------VGQ-PIQT-YEEFAACLPADECRYAIYDFDF
Human		MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDP-FKHFVGMLPEKDCRYALYDASF
Yeast		EINGNEGKRSKIVFFTWSDDTAPVRSKMVYASSKDALRRALNGVSTDVQGTDFSEVSYDS-VLERVSRGAGSH
Dict. D.		KEEG--AQKSKICFVAWCPDTANIKKKMMATSSKDSLRKACVGIQVEIQGTDASEVK-DSCFYEKCTK
Ac. Cast.		QVDG--GQRNKITFILWAPDSAPIKSKMMYTSTKDSIKKKLVGIQVEVQATDAAEISEDA-VSERAKKDVK
A.T.		VTAEN-CQKSKIFFIAWCPDIAKVRSKMIYASSKDRFKRELDGIQVELQATDPTEMDLDV-FRSRAN
Human		ETKE--SRKEELMFFLWAPDLAPLKSKMIYASSKDAIKKKFQGIKHECQANGP-E-DLNRACIAEKLGGSLIVAFEGCPV

Dashes are gaps introduced to optimize alignments. Identical or highly conserved residues (at least four out of the five) are shown in bold letters. Only K = R, D = E, V = I = L = M, Y = F are considered as highly conservative homologies. A.T., Arabidopsis Thaliana; Dict. D., Dictyostelium discoideum; Ac. Cost., Acanthamoeba castellanii.