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. 1997 Jun 16;137(6):1287–1307. doi: 10.1083/jcb.137.6.1287

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Myosin isozyme location in sensory epithelia of auditory and vestibular organs. Green shading indicates myosin location; darker green indicates higher myosin concentration. (Myosin-Iβ) The strongest labeling is in the pericuticular necklace; modest amounts of myosin-Iβ are found in the hair cell cytoplasm and apical surfaces of peripheral cells. Within the bundle, myosin-Iβ labeling is focused toward stereociliary tips. (Myosin-V) No labeling in hair cells; all labeling in sensory epithelium apparently is associated with afferent nerve fibers. Myosin-V is found in both calyx and bouton synaptic terminals. (Myosin-VI) Hair cells are strongly labeled; supporting cells are not labeled at all. The highest concentration is in cuticular plates and pericuticular necklaces. There is light hair bundle labeling in frog but not in guinea pig. (Myosin-VIIa) Myosin-VIIa is expressed exclusively in hair cells, throughout the cell bodies and along the lengths of stereocilia. In frog, myosin-VIIa is found throughout stereocilia but most strikingly in a band immediately above the basal connectors (also called ankle links); substantial amounts are also found in the pericuticular necklace.