Table II.
LD50s and Plaquing Results
| Strain | LD50 in mice | Plaque size | Source or reference§ | |||
|---|---|---|---|---|---|---|
| (CFU) | %*± SD (n)‡ | |||||
| 10403S | 1–3 × 104 | 100 | Portnoy et al., 1988 | |||
| DP-L1552 | 3.2 × 104 | 88.3 ± 6.0‖ (10) | Camilli et al., 1993 | |||
| DP-L1935 | 2 × 105 | 66.7 ± 5.8‖ (18) | Smith et al., 1995 | |||
| DP-L2296 | <5 × 104 | 71.0 ± 6.4 (17) | This study | |||
| DP-L2787 | 3.5 × 105 | 66.4 ± 4.3 (10) | This study | |||
| DP-L1936 | 5 × 106 | 34.0 ± 5.2‖ (15) | Smith et al., 1995 | |||
| DP-L2483 | 1.6 × 106 | 53.1 ± 5.8 (16) | This study | |||
| DP-L2869 | ND | 36.7 ± 3.3 (5) | This study |
*
Relative percentage of diameter of plaques formed in L2 cells by mutant strains in comparison with the wild-type strain.
‡
(n) = number of plaquing experiments.
§
For LD50s' data.
‖
Plaquing results from this study were combined with previously reported results from this laboratory (Smith et al., 1995).