Figure 1.

Bcl-2 mediates ER Ca²⁺ uptake. Uptake of ⁴⁵Ca²⁺ was measured in digitonin-permeabilized cells in the absence (A) or presence of oxalate (B–F), and in the absence (A and B) or presence of 5 nM TG (C), 10 nM TG (D), 20 nM TG (E), or 100 nM TG (F). Open symbols, WEHI7.2 cells; closed symbols, W.Hb12 cells. Symbols represent the mean of duplicate determinations in a single experiment that was repeated at least twice with a similar result.