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. 1997 Sep 22;138(6):1229–1238. doi: 10.1083/jcb.138.6.1229

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Mutants of Eug1p converting CXXS active site motifs to CXXC show improved growth. Shown are: yeast cells deleted for the chromosomal copies of PDI1 and EUG1 containing plasmids with PDI1 (PDI), wild-type EUG1 under control of the PDI1 promoter (Eug1p) or a mutant form of EUG1 containing a CIHC-CLHC active site sequences (Eug1p-CXXC). EUG1 expressed from the PDI1 promoter is able to complement a pdi1 deletion, albeit with a considerably reduced growth rate. The growth deficiency of this strain is essentially corrected by the introduction of CXXC active site motifs.