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. 1997 Sep 22;138(6):1425–1435. doi: 10.1083/jcb.138.6.1425

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Cytoplasmic domain mutants of muPECAM-1. The PECAM-1 cytoplasmic domain is encoded by exons 9–16. A series of muPECAM-1 mutants in which specific exons encoding regions of the cytoplasmic domain had been deleted were constructed and expressed in L cells as described in Materials and Methods. The extracellular domain and transmembrane regions were wild type and the same for each construct. The figure indicates: the name of each construct; the regions of exon 14 that were deleted or mutated (note: muPECAM-Δ5′ exon 14 is deleted in the sequence ALGRTRATET; muPECAM-Δ3′ exon 14 is deleted in the sequence VYSEIRKVDP); and the aggregation behavior of murine L cells stably expressing each construct.