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. 1998 Jan 12;140(1):233–245. doi: 10.1083/jcb.140.1.233

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Schematic representation of the wound healing response to perivascular electric injury and the topographic pattern of neointima formation in u-PAR^+/+ and u-PAR^−/− arteries. The media of an uninjured mouse femoral artery consists of two to three layers of smooth muscle cells. There are no smooth muscle cells in the intima. 2 d after injury, the injured segment in the media is depleted of smooth muscle cells. Within 1 wk after injury, cells begin to repopulate the media and a small neointima is formed at the borders of the injury. The insert shows the presumed migration of smooth muscle cells across the internal elastic lamina, within the media, and alongside the lumen. Within 3–4 wk after injury, the media is repopulated and the neointima has uniformly developed throughout the whole injured region. The vertical lines below each artery denote the equally spaced locations that were used for the topographic analysis in Tables II, III and Fig. 4.