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. 1998 Jan 12;140(1):233–245. doi: 10.1083/jcb.140.1.233

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Ultrastructural localization of u-PA in vivo. Immunogold labeling of u-PA in u-PAR^+/+ (a–c) and u-PAR^−/− (d and e) arteries, revealing u-PA bound to the cell surface (a–c, arrows) on endothelial cells (EC) or smooth muscle cells (SMC), or associated with the extracellular matrix (ECM) (b and c, arrowheads) in u-PAR^+/+ arteries. Note the presence of u-PA gold particles on cell projections (a), and on collagen (CL) fibers in the extracellular matrix (b). In contrast, in u-PAR^−/− arteries, u-PA gold particles were predominantly detected in the pericellular milieu associated with extracellular matrix components (d and e, arrowheads). Note the paucity of u-PA gold particles on the elastin fibers of the internal elastic lamina (IEL) (e). Gold particles labeling u-PA were also found in secretory granules inside u-PAR^−/− cells (d and e, SG).