Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1998 Jan 12;140(1):233–245. doi: 10.1083/jcb.140.1.233

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Plasmin(ogen) dependent activation of matrix metalloproteinases. (a) gelatin zymography after MMP-9 immunoprecipitation; (b and c) autoradiograph from metabolically labeled macrophage-conditioned medium after MMP-9 (b) or MMP-13 (c) immunoprecipitation. In the absence of plasminogen (−Plg), only the zymogen proMMP-9 (∼92 kD, a and b) and proMMP-13 (∼57 kD, c) are present in the conditioned medium from macrophages of all genotypes. In the presence of plasminogen (+Plg; 10 μg/ml), these proforms are processed to the active MMP-9 (∼82 kD) and MMP-13 (∼45-kD doublet and partially processed forms) by wild-type (WT) and u-PAR–deficient (u-PAR ^−/−) macrophages but not by u-PA– deficient (u-PA ^−/−) macrophages.