Table III.
Topographic Pattern of Neointimal Cell Accumulation
| Time after injury | Genotype | Topographic location across injury | ||||||
|---|---|---|---|---|---|---|---|---|
| Border (position 1) | Center (position 5) | Border (position 10) | ||||||
| 1 week | u-PAR+/+ | 124 ± 29 | 47 ± 14* | 117 ± 25 | ||||
| u-PAR−/− | 121 ± 31 | 30 ± 10* | 166 ± 23 | |||||
| 3 weeks | u-PAR+/+ | 184 ± 47 | 153 ± 28 | 219 ± 32 | ||||
| u-PAR−/− | 201 ± 36 | 158 ± 40 | 159 ± 33 | |||||
The data represent the mean ± SEM of the number of neointimal cells in at least seven arteries, determined at similar relative topographic locations at the uninjured borders or throughout the injured arterial segment. The topographic positions are indicated on the schematically represented arteries in Fig. 1.
*
P < 0.05 versus uninjured border (locations 1 or 10) by analysis of variance with Bonferroni correction.