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. 1997 Dec 15;139(6):1533–1543. doi: 10.1083/jcb.139.6.1533

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Both larval and adult intestinal cells undergo apoptosis upon T₃ treatment in vitro. Cells were dissociated from intestine of stage 57/58 or 64 tadpoles and all of the cells were cultured together in vitro in the presence or absence of 100 nM T₃. Cell death was analyzed by using the DNA fragmentation ELISA assay. The cells were predominantly epithelial but a higher portion of mesenchymal cells were present in stage 64 tadpole intestine (McAvoy and Dixon, 1977; Ishizuya-Oka and Shimozawa, 1987a ). Note that cell death were detected for both the larval and adult intestinal cells. Slightly lower levels of T₃-induced DNA fragmentation were observed at stage 64, probably reflecting the presence of a slightly higher percentage of nonepithelial cells.