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ET-1 dependent contractility of myofibroblasts. Contraction assays were performed as described in Materials and Methods. The change in diameter of the collagen gel was measured after 24 and 48 h in the absence of ET-1 (○) after addition of 10−10 M ET-1 (•) and 5 × 10−7 M ET-1 antagonist (▾). Each contraction assay was performed in triplicate. Data are presented as mean values ± standard error.
