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. 1997 Dec 29;139(7):1597–1610. doi: 10.1083/jcb.139.7.1597

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The differential compartmentalization typical of interphase is established during late telophase/G1. BrdU-labelled late replicating DNA was probed with an anti–BrdU mAb (green) and nuclear lamin B with an anti–lamin antiserum (red) during (A) early telophase and (B) late telophase/early G1. In both cases, serial optical sections were taken at 0.33–0.4-mm intervals, digitally converted into 3D images and are shown here as stereo pairs. During early telophase (A), most of the labelled chromatin (green) occupies the internal nucleoplasm; frequent connections are seen with internal projections of lamin staining. In late telophase/early G1 cells (B), most of the late replicating chromatin (green) has relocated to the nuclear periphery. Bar, 1 μm.