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. 1997 Dec 29;139(7):1597–1610. doi: 10.1083/jcb.139.7.1597

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Compartmentalization of DNA is independent of chromosome number. CHF cells pulse labelled with BrdU at defined stages of S phase (stages 1–5) were induced to micronucleate. Each picture shows a single cell. (A and B) Stage 1 micronuclei displaying different extents of micronucleation. (C) Stage 2 micronuclei. (D) Stage 3 micronuclei; in addition to predominant peripheral labelling, there are internal ring-shaped chromatin assemblies in most micronuclei, the more prominent of which are depicted (arrows). (E) Stage 4 micronuclei. (F) Stage 5 micronuclei. Note the striking resemblance to replication patterns seen in intact nuclei. Bar, 10 μm.