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. 1998 Mar 23;140(6):1519–1534. doi: 10.1083/jcb.140.6.1519

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Ep-CAM expression identifies the epithelial compartment of the human fetal pancreas. Triple immunofluorescence, followed by confocal microscopic analysis, was performed on 8-μm cryostat sections from a human fetal pancreas of 18 wk to simultaneously identify Ep-CAM–, insulin-, and glucagon-positive cells. (A) Ep-CAM–specific immunoreactivity that highlights the cell– cell boundaries of epithelial cells. The strongest immunoreactivity for Ep-CAM is detected in cell clusters budding from the ducts (asterisks). Notably, many cell clusters emerging from the ductal epithelium contain large numbers of glucagon- (B) and insulin-positive cells (C). (D) Combined fluorophore spectra. Yellow color results from the colocalization of green and red fluorescences, specific for Ep-CAM and insulin, respectively. Representative of nine independent experiments using five independent donors (18–20 wk of gestation). Bar, 50 μm.