Table II.

Distribution of Ki-67–positive Cells in the Human Pancreas

Cell types		Ki-67–positive cells		Proliferation index
Fetal pancreas
Ductal		11.70 [122]*		0.48‡
Endocrine		14.87 [155]		0.69
Epithelial undifferentiated		52.01 [542]		1.50
Adult pancreas
Ductal		39.12 [367]§		2.79 ¶
Endocrine		0.95 [9]		0.47
Acinar		44.80 [421]		0.60

^* Expressed as percentage of total number of cells counted. [number of cells counted].  

^‡ Calculated by correcting the percentage of Ki-67–positive cells for the relative proportion of pancreatic cell types (i.e., ductal cells = 24%, endocrine cells = 21.5%, epithelial undifferentiated = 34.5%, stroma = 20%) (Cirulli, V., unpublished data). Number of fields scored = 96. Total number of cells counted = 819. Number of donors = 3 (fetal pancreata at gestational age 18–20 wk).  

^§Expressed as percentage of total number of cells counted. [Number of cells counted].  

^¶Calculated by correcting the percentage of Ki-67–positive cells for the relative proportion of the different pancreatic cell types (i.e., ductal cells = 14%, endocrine cells = 2%, epithelial undifferentiated = 74%, stroma = 10%) (for review see Githens, 1988). Number of fields scored = 202. Total number of cells counted = 797. Number of donors = 3 (age: 20, 32, and 56 yr).