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. 1998 Mar 23;140(6):1395–1405. doi: 10.1083/jcb.140.6.1395

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(A) Coordination between single-headed molecules moving a microtubule. In this example, the binding of the fourth head and its subsequent conformational change is hypothesized to accelerate the unbinding of the second, attached head and to move the microtubule a small distance to a position that will allow one of the other detached heads to bind. (B) Model of organelle transport by monomeric KIF1 molecules. If these kinesin-related proteins are coordinated like single-headed kinesin, then continuous motility would require only four to six molecules on the surface of a mitochondrion.

(A) Coordination between single-headed molecules moving a microtubule. In this example, the binding of the fourth head and its subsequent conformational change is hypothesized to accelerate the unbinding of the second, attached head and to move the microtubule a small distance to a position that will allow one of the other detached heads to bind. (B) Model of organelle transport by monomeric KIF1 molecules. If these kinesin-related proteins are coordinated like single-headed kinesin, then continuous motility would require only four to six molecules on the surface of a mitochondrion.