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. 1998 Mar 23;140(6):1347–1356. doi: 10.1083/jcb.140.6.1347

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Pathway of FBPase degradation. Glucose induces FBPase targeting and sequestration into the vesicles. FBPase is then delivered from the vesicles to the vacuole for degradation. Glucose also induces the synthesis and binding of Vid24p to the vesicles. Vid24p is required to deliver FBPase from the vesicles to the vacuole for degradation. In the absence of functional Vid24p, FBPase accumulates in the vesicles. The downstream events after Vid24p binding to the vesicles have not been established. The vesicles may fuse directly with the vacuole. Alternatively, the vesicles may fuse with each other or with different types of vesicles and then with the vacuole. It is also possible that the vesicles aggregate before fusion with the vacuole.