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. 1998 Mar 9;140(5):1255–1263. doi: 10.1083/jcb.140.5.1255

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The role of ERK activity on endothelial cell migration. Endothelial cell migration on vitronectin in modified Boyden chambers of serum-starved HUVECs was induced with bFGF (25 ng/ml) or VEGF (25 ng/ml) in the presence or absence of 50 μM PD98059 for 2 h as described in Materials and Methods. ERK activity as detected by phosphorylation of MBP in an in vitro kinase assay was measured in parallel HUVEC cultures after treatment with bFGF, VEGF, or PD98059 for 30 min as described in the Materials and Methods. Migration data are expressed as the mean number of cells quantitated in at least three 10× microscope fields ± SD (n = 3). The kinase data are from a representative experiment.