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. 1998 Mar 9;140(5):1255–1263. doi: 10.1083/jcb.140.5.1255

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Model depicting kinetics of MAP kinase activity during angiogenesis and the distinct requirements for ligation of integrin αvβ3 for immediate versus sustained MAP kinase activity. A rapid increase in bFGF-induced MAP kinase activity that is independent of integrin αvβ3 is followed by a sustained MAP kinase activity which requires αvβ3 ligation.