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. 1998 Apr 6;141(1):199–208. doi: 10.1083/jcb.141.1.199

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Multiple sequence alignments of the MAGUK domains of canine ZO-3, human ZO-1 (44), canine ZO-2 (7), Drosophila TamA (41), and dlg-A (46), constructed with GCG PILEUP. The GUK domain is also compared with the yeast guanylate kinase sequence (8). Dark shaded regions indicate identity to the ZO-3 sequence, lighter shades are conserved aa substitutions. Amino acids in the PDZ domains believed to be important in protein–protein interactions (32) are marked (+), as are the aa involved in ATP (bar), GMP (*) and Mg²⁺ (o) binding in the GUK domain (26). # indicates the aa of the putative leucine zipper motif.