Figure 2.

Scully and its mammalian homologues. Alignment of Scully (upper row) and the mammalian consensus derived from: Bos taurus type II l-3-hydroxyacyl-CoA dehydrogenase (AB002156; Furuta et al., 1997); Homo sapiens ERAB (U96132; Yan et al., 1997) and U73514 (Zhuchenko et al., unpublished data); and Mus musculus ERAB (U96116; Fu et al., unpublished data). Functional domains are boxed and shaded; the first is the cofactor-binding domain and the second is the catalytic domain. Single amino acid mutations scu¹⁷⁴ and scu^S152 are indicated with asterisks. Frameshift mutations scu³¹²⁷ and scu⁴⁰⁵⁸ are indicated with arrowheads. Amino acids conserved in more than 90% of the short-chain alcohol dehydrogenases sequences (Jörnvall et al., 1995) are underlined. The complete genomic sequence of scully gene has been submitted to the DDBJ/EMBL/GenBank databases under accession No. Y15102.