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. 1998 May 18;141(4):1083–1093. doi: 10.1083/jcb.141.4.1083

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α_vβ₃ integrin mediates osteopontin-induced endothelial cell survival. (A) Cells were plated on osteopontin-coated surfaces in serum-free medium. Soon after spreading (∼2 h after plating), F11 monoclonal antibody (triangles) or mouse IgG (squares) at the concentration of 50 μg/ml were added. Nuclear morphology was assessed at 24, 48, and 72 h. (B) Cells were plated on polylysine, osteopontin (OPN), F11, or mouse IgG (mIgG)-coated surfaces in serum-free medium. 48 h after plating, cells were stained with the nuclear dye Hoechst 33342, and nuclear morphology was assessed. Data represent the average of triplicates ± SD of a representative experiment.